Work

Sensitivity-enhanced detection of non-labile proton and carbon NMR spectra on water resonances

Year: 2017

Type: article

Abstract: H NMR spectra were detected in this fashion with about two-fold SNR amplification vis-à-vis conventionally detected spectroscopies. When combined with non-uniform sampling principles, this methodology thus becomes a sensitive alternative to detect non-exchangeable species in biomolecules. Still, multiple parameters including the scalar couplings and solvent exchange rates, will affect the efficiency and consequently the practicality of the overall experiment.

Source: Physical Chemistry Chemical Physics

DOI: 10.1039/c7cp07046b

Authors: Mihajlo Novakovic, Ricardo P. Martinho, Gregory L. Olsen, Michael S. Lustig, Lucio Frydman

Institutions: Weizmann Institute of Science, University of California, Berkeley

Language: English

Topic: Advanced NMR Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Israel Science Foundation, Planning and Budgeting Committee of the Council for Higher Education of Israel, H2020 Marie Skłodowska-Curie Actions

Awards: G2776991352, G6464662356, EUROPOL