Endogenous Cell-based Therapy Using Cyclosporine a Promotes Cognitive Recovery in a Mouse Model of Stroke
Year: 2017
Type: dissertation
Abstract: Post-stroke executive function (EF) deficits can severely impact the quality of life. Current treatments provide limited motor or cognitive recovery. Recently, an endogenous repair strategy using Cyclosporine A (CsA) promoted neural stem and progenitor cells [collectively termed neural precursor cells (NPCs)] migration to the infarct site, tissue regeneration and functional recovery following sensorimotor stroke. Herein, we tested the efficacy of CsA in improving EF deficits in a cognitive stroke model in mice. The medial prefrontal cortical (mPFC) stroke produced long-term EF impairments in the Puzzle Box Task. CsA treatment increased the size of the NPC pool at day 7 and promoted NPC migration to the infarct site at day 60 post-stroke. Early CsA administration was not neuroprotective and did not affect neural degeneration or lesion volume. Long-term CsA treatment improved post-stroke cognitive performance at 3 and 5 weeks. We suggest CsA is a promising therapeutic candidate for post-stroke cognitive recovery.
Source: TSpace (University of Toronto)
Author: Labeeba Nusrat
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2770642238