Admixture mapping in the Hispanic Community Health Study/Study of Latinos reveals regions of genetic associations with blood pressure traits
Year: 2017
Type: article
Abstract: Admixture mapping can be used to detect genetic association regions in admixed populations, such as Hispanics/Latinos, by estimating associations between local ancestry allele counts and the trait of interest. We performed admixture mapping of the blood pressure traits systolic and diastolic blood pressure (SBP, DBP), mean arterial pressure (MAP), and pulse pressure (PP), in a dataset of 12,116 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Hispanics/Latinos have three predominant ancestral populations (European, African, and Amerindian), for each of which we separately tested local ancestry intervals across the genome. We identified four regions that were significantly associated with a blood pressure trait at the genome-wide admixture mapping level. A 6p21.31 Amerindian ancestry association region has multiple known associations, but none explained the admixture mapping signal. We identified variants that completely explained this signal. One of these variants had p-values of 0.02 (MAP) and 0.04 (SBP) in replication testing in Pima Indians. A 11q13.4 Amerindian ancestry association region spans a variant that was previously reported (p-value = 0.001) in a targeted association study of Blood Pressure (BP) traits and variants in the vitamin D pathway. There was no replication evidence supporting an association in the identified 17q25.3 Amerindian ancestry association region. For a region on 6p12.3, associated with African ancestry, we did not identify any candidate variants driving the association. It may be driven by rare variants. Whole genome sequence data may be necessary to fine map these association signals, which may contribute to disparities in BP traits between diverse populations.
Source: PLoS ONE
Institutions: Brigham and Women's Hospital, Harvard University, National Institutes of Health, University of Washington, San Diego State University, Albert Einstein College of Medicine, Northwestern University, University of Illinois Chicago, Loyola University Chicago, University of North Carolina at Chapel Hill, National Heart, Lung, and Blood Institute, Framingham Heart Study, Fred Hutch Cancer Center
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,382
Funders: Office of Dietary Supplements, University of Miami, Northwestern University, San Diego State University, University of Washington, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Institute of Dental and Craniofacial Research, National Institute on Minority Health and Health Disparities
Awards: G1004541261, G1017297203, G1042216835, G1081972346, G1301356587, G1312369436, G1362217241, Hispanic Community Health Study, G1455175283, Trans-ethnic meta-analysis of blood pressure in African and European ancestries, G1587824183, G1666450717, G1888983140, G1917633662, G2128161193, G2135211244, G2135293100, Rare variants and NHLBI traits in deeply phenotyped cohorts, G232264632, G2466919156, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2501967490, G2528054427, G2575730562, G2644289446, G2645088300, G2878178050, G2970637568, G3062787641, Hispanic Community Health Study, G3677686024, G3838006641, G3952816605, Rare variants and NHLBI traits in deeply phenotyped cohorts, G4121762840, Hispanic Community Health Study, G4441691082, G4552920371, G4752697780, G4860668542, G4989378220, G50080621, G51047235, G5129651400, G514778300, G5223154479, G528357465, G5365244667, G5397198720, G543802643, G555858244, G5739677117, G5865322400, G5878028785, G5906656038, G5935820280, G594985637, G5993399974, G6045475270, G6075306088, G6156511736, G6585687856, G6630573766, G6705035318, Leveraging ancestry to map kidney loci, G6744188800, G7057037114, G7203655167, G7239480477, G7272721675, G7278742613, G729036485, G7408420985, G7513901258, G7678550560, G8102260223, G820454163, G8386326007, HISPANIC COMMUNITY HEALTH STUDY-268065233, G8840902395, G8904081916, UNC Center for Environmental Health and Susceptibility, G913983815, G954279374
OpenAlex ID: W2770866939