Year: 2017
Type: review
Abstract: Stem cells interpret signals from their microenvironment while simultaneously modifying the niche through secreting factors and exerting mechanical forces. Many soluble stem cell cues have been determined over the past century, but in the past decade, our molecular understanding of mechanobiology has advanced to explain how passive and active forces induce similar signaling cascades that drive self-renewal, migration, differentiation or a combination of these outcomes. Improvements in stem cell culture methods, materials and biophysical tools that assess function have improved our understanding of these cascades. Here, we summarize these advances and offer perspective on ongoing challenges.
Source: Development
DOI: 10.1242/dev.158469
Authors: Aditya Kumar, Jesse K. Placone, Adam J. Engler
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: bronze
Awards: Development of novel hiPSC-seeded, 3D printed vascular grafts, Predoctoral Training in Translational Musculoskeletal Research, Strain-Activated Signaling within Cell Adhesions Dictates Cell Fate, Mechanogenetics: An Integrated Approach to Aging in Muscle Dysfunction, G8732084670, G9000027160
OpenAlex ID: W2771052038