Work

Human longevity: 25 genetic loci associated in 389,166 UK biobank participants

Year: 2017

Type: article

Study design: Observational Study

Abstract: =1,181) in UK Biobank. The results suggest that human longevity is highly polygenic with prominent roles for loci likely involved in cellular senescence and inflammation, plus lipid metabolism and cardiovascular conditions. There may also be gender specific routes to longevity.

Source: Aging

DOI: 10.18632/aging.101334

Authors: Luke C. Pilling, Chia-Ling Kuo, Kamil Sicinski, Jone Tamosauskaite, George A. Kuchel, Lorna W. Harries, Pamela Herd, Robert Wallace, Luigi Ferrucci, David Melzer

Institutions: University of Exeter, Royal Devon and Exeter Hospital, Exeter Hospital, UConn Health, University of Wisconsin–Madison, University of Connecticut, University of Iowa, National Institute on Aging

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, Medical Research Council, National Institute on Aging

Awards: Aging Together: Brothers and Sisters of the Wisconsin Longitudinal Study, GENETIC AND ENVIRONMENTAL INFLUENCES ON AGEING WELL IN THE UK BIOBANK, The Wisconsin Longitudinal Study: Tracking the Life Course, G6376995420, The Wisconsin Longitudinal Study: As We Age, Health and Retirement Study: Yrs 35-40, Center for Demography of Health and Aging

OpenAlex ID: W2771230199

FWCI: 14.18

Cites: 44

Cited by: 210

Related to: 10