Correlation between biochemical and hemodynamic parameters of endothelial dysfunction in hypertensive and diabetic type 2 subjects
Year: 2007
Type: article
Abstract: "Leptin is a polypeptide hormone secreted by the adipose tissue. It works mainly in the hypothalamus acting on thirst but it has been also described that it may exert a regulatory control on the blood pressure, given its closed connections with the inflammatory and endothelial systems. Objective: In this study serum Leptin, serum reactive C protein (RCP) and serum nitric oxide were measured in healthy, hypertensive and type 2 diabetic subjects under cold pressure test (CPT). Design and methods: We examined forty three (43) subjects (males and females) with ages ranging between 25 and 60 years divided en three groups: 15 healthy, 13 hypertensive and 15 type 2 diabetic subjects. A complete history and physical exam with electrocardiogram was carried out in all subjects. Antihypertensive therapy was discontinued two weeks prior to the experimental study and antidiabetic therapy was continued in all diabetic subjects and this was only omitted the day of the study. During 30 min, 0.9% saline solution was infused intravenously. The cardiovascular parameters (systolic and diastolic BP, heart rate) were measured at the minute 0, 16 and 30. CPT was performed to assess the cardiovascular reactivity at the minute 15. In addition, serum parameters were measured at the beginning and at the end of the study and statistical analysis was performed. Results: CPT caused in all subjects a significant increase in BP and heart rate. There were no significant differences to RCP and Leptin in all groups, although we observed significant differences for nitric oxide (P < 0.05). RCP levels were directly associated with nitric oxide levels, and this association was strongest in subjects with CPT hyper reactivity. Conclusion: Leptin could be considered as a complement achieving endothelial dysfunction diagnosis, given its inverse correlation with CPT hyper reactivity in all subjects."
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W27714946