Work

A centrosomal scaffold shows some self-control

Year: 2017

Type: article

Abstract: The scaffolding protein AKAP350A is known to localize to the centrosome and the Golgi, but the molecular details of its function at the centrosome remain elusive. Using structure–function analyses, protein interaction assays, and super-resolution microscopy, Kolobova et al. now identify AKAP350A's specific location and protein partners at the centrosome. The authors further define an autoregulatory mechanism that likely controls AKAP350A's ability to nucleate microtubule growth.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.h117.806018

Authors: Ramya Varadarajan, John A. Hammer, Nasser M. Rusan

Institutions: National Institutes of Health, National Heart, Lung, and Blood Institute

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute