Overexpression of β1 integrin contributes to polarity reversal and a poor prognosis of breast invasive micropapillary carcinoma
Year: 2017
Type: article
Abstract: // Bingbing Liu 1, 2, 3, * , Xia Zheng 1, 2, * , Fanfan Meng 1, 2 , Yunwei Han 1, 2 , Yawen Song 1, 2 , Fangfang Liu 1, 2 , Shuai Li 1, 2 , Lanjing Zhang 1, 2, 4, 5, 6, 7 , Feng Gu 1, 2 , Xinmin Zhang 8 and Li Fu 1, 2 1 Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China 2 Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China 3 Department of Pathology, Third Central Hospital of Tianjin, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health Ministry,Tianjin, China 4 Department of Pathology, University Medical Center of Princeton, Plainsboro, NJ, USA 5 Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA 6 Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA 7 Department of Pathology, Robert Wood Johnson Medical School, and Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA 8 Department of Pathology, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, USA * These authors contributed equally to this work Correspondence to: Li Fu, email: [email protected] Xinmin Zhang, email: [email protected] Feng Gu, email: [email protected] Keywords: invasive micropapillary carcinoma; polarity reversal; β1 integrin; metastasis; breast Received: September 07, 2017 Accepted: November 17, 2017 Published: November 30, 2017 ABSTRACT Invasive micropapillary carcinoma (IMPC) of the breast is a highly aggressive breast cancer. Polarity reversal exemplified by cluster growth is hypothesized to contribute to the invasiveness and metastasis of IMPC. In this study, we demonstrate that levels of β1 integrin and Rac1 expression were greater in breast IMPC than in invasive breast carcinoma of no specific type and paraneoplastic benign breast tissue. We show that silencing β1 integrin expression using the β1 integrin inhibitor AIIB2 partially restored polarity in IMPC primary cell clusters and downregulated Rac1. Thus, overexpression of β1 integrin upregulates Rac1. Univariate analysis showed that overexpression of β1 integrin and Rac1 was associated with breast cancer cell polarity reversal, lymph node metastasis, and poor disease-free survival in IMPC patients. Multivariate analysis revealed that polarity reversal was an independent predictor of poor disease-free survival. These findings indicate that overexpression of β1 integrin and the resultant upregulation of Rac1 contribute to polarity reversal and metastasis of breast IMPC, and that β1 integrin and Rac1 could be potential prognostic biomarkers and targets for treatment of breast IMPC.
Source: Oncotarget
Authors: Bingbing Liu, Xia Zheng, Fanfan Meng, Yunwei Han, Yawen Song, Fangfang Liu, Shuai Li, Lanjing Zhang, Feng Gu, Xinmin Zhang, Li Fu
Institutions: Tianjin Medical University Cancer Institute and Hospital, Tianjin Third Central Hospital, Tianjin Medical University, Rutgers, The State University of New Jersey, University Medical Center of Princeton, Rutgers Cancer Institute, Cooper University Hospital, Cooper Medical School of Rowan University
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2772009102