Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults
Year: 2017
Type: article
Study design: Observational Study
Abstract: Traffic noise has been linked to diabetes, with limited understanding of its mechanisms. We hypothesize that night-time road traffic noise (RTN) may impair glucose homeostasis through circadian rhythm disturbances. We prospectively investigated the relationship between residential night-time RTN and subsequent eight-year change in glycosylated hemoglobin (ΔHbA1c) in 3350 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), adjusting for diabetes risk factors and air pollution levels. Annual average RTN (Lnight) was assigned to participants in 2001 using validated Swiss noise models. HbA1c was measured in 2002 and 2011 using liquid chromatography. We applied mixed linear models to explore RTN–ΔHbA1c association and its modification by a genetic risk score of six common circadian-related MTNR1B variants (MGRS). A 10 dB difference in RTN was associated with a 0.02% (0.003–0.04%) increase in mean ΔHbA1c in 2142 non-movers. RTN–ΔHbA1c association was modified by MGRS among diabetic participants (Pinteraction = 0.001). A similar trend in non-diabetic participants was non-significant. Among the single variants, we observed strongest interactions with rs10830963, an acknowledged diabetes risk variant also implicated in melatonin profile dysregulation. Night-time RTN may impair glycemic control, especially in diabetic individuals, through circadian rhythm disturbances. Experimental sleep studies are needed to test whether noise control may help individuals to attain optimal glycemic levels.
Authors: Ikenna Eze, Medea Imboden, Maria Foraster, Emmanuel Schaffner, Ashish Kumar, Danielle Vienneau, Harris Héritier, Franziska Rudzik, Laurie Thiesse, Reto Pieren, Arnold Von Eckardstein, Christian Schindler, Mark Brink, Jean-Marc Wunderli, Christian Cajochen, Martin Röösli, Nicole Probst-Hensch
Institutions: Swiss Tropical and Public Health Institute, University of Basel, Karolinska Institutet, University Hospital of Basel, Universitäre Psychiatrische Kliniken Basel, Swiss Federal Laboratories for Materials Science and Technology, University of Zurich, University Hospital Zurich, Federal Office for the Environment
Language: English
Topic: Noise Effects and Management
Subfield: Speech and Hearing
Field: Health Professions
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,016
Funders: National Science Foundation, Freiwillige Akademische Gesellschaft, Wellcome Trust, European Commission, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Bundesamt für Gesundheit, Chinese Society of Clinical Oncology, Lungenliga Schweiz, Abbott Diagnostics, Bundesamt für Umwelt
Awards: SAPALDIA COHORT STUDY: Impact of environmental and personal risk factors on the occurrence, course, remission and progression of respiratory disease in the swiss population-data analysis, SAPALDIA COHORT STUDY: Impact of air pollution on the cardiovascular and respiratory system in the Swiss population, SAPALDIA Cohort on Healthy Aging, G2837121351, G2957143966, The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population., G3158343894, Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), Swiss Study on Air Pollution and Lung Diseases in Adults: Mortality follow-up extension., G3540089817, G3708726189, G3831390383, Swiss study on air pollution and lung diseases in adults (SAPALDIA study), G5125551685, Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), Air Pollution Exposure Assessment in Eight Swiss Areas, The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population., Swiss Study on Air Pollution and Lung Diseases in Adults: Participants'Follow-up and Further Analysis., Transportation noise, annoyance, sleep and cardiometabolic risk: an integrated approach on short- and long-term effects, G6569494901, G6860857771, G7051184245, G7053373122, G7262634952, G8281345491, SAPALDIA COHORT STUDY: Mortality follow-up, maintenance of the cohort, the biobanks and the data bases.
OpenAlex ID: W2772139245