Work

Inadequate glycemic control in patients receiving parenteral nutrition lowers survival: A retrospective observational trial

Year: 2017

Type: article

Abstract: Background & aims Parenteral Nutrition (PN) has been shown to cause glycemic deregulation, whether patients have type 2 diabetes (T2DM) or not, causing elevated mortality, despite intensive insulin treatment. Long-term effects, however, are unclear. Methods A retrospective observational study was performed. 226 patients of the UZ Brussel, both T2DM patients and non-diabetics, who received PN in 2013 or 2014, were analyzed on the presence of hyperglycemia and hypoglycemia, as well as mortality in-hospital and after 6 months. Results Here we show that T2DM patients displaying either hyper- or hypoglycemia, had a significant higher mortality. This was the case both in-hospital and after 6 months. Non-diabetics undergoing hyperglycemia had a similar fate, but not when these patients had hypoglycemic events. Conclusion Whether PN-receiving patients had T2DM or were non-diabetic, hyperglycemia was related to mortality, both in-hospital and after 6 months, whereas hypoglycemia was only related to mortality in T2DM patients.

Source: Clinical Nutrition Experimental

DOI: 10.1016/j.yclnex.2017.12.001

Authors: Elien Coudenys, Elisabeth De Waele, Garmt Meers, Hilde Collier, Joeri J. Pen

Institutions: Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel

Language: English

Topic: Hyperglycemia and glycemic control in critically ill and hospitalized patients

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,200