Work

Hydrogen-Bonding-Assisted Brønsted Acid and Gold Catalysis: Access to Both ( E )- and ( Z )-1,2-Haloalkenes via Hydrochlorination of Haloalkynes

Year: 2017

Type: article

Abstract: We have developed an efficient synthesis of both (Z)- and (E)-chlorohaloalkenes via hydrochlorination of haloalkynes, based on two distinct hydrogen-bond-network-assisted catalytic systems: Brønsted acid catalysis and gold catalysis. Both systems offer high stereoselectivity, good chemical yields, and diverse functional group tolerance.

Source: ACS Catalysis

DOI: 10.1021/acscatal.7b03563

Authors: Xiaojun Zeng, Shiwen Liu, Gerald B. Hammond, Bo Xu

Institutions: Donghua University, University of Louisville

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500