Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts
Year: 2017
Type: review
Study design: Observational Study
Abstract: BACKGROUND: Regular fish and omega-3 consumption may have several health benefits and are recommended by major dietary guidelines. Yet, their intakes remain remarkably variable both within and across populations, which could partly owe to genetic influences. OBJECTIVE: To identify common genetic variants that influence fish and dietary eicosapentaenoic acid plus docosahexaenoic acid (EPA+DHA) consumption. DESIGN: We conducted genome-wide association (GWA) meta-analysis of fish (n = 86,467) and EPA+DHA (n = 62,265) consumption in 17 cohorts of European descent from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium Nutrition Working Group. Results from cohort-specific GWA analyses (additive model) for fish and EPA+DHA consumption were adjusted for age, sex, energy intake, and population stratification, and meta-analyzed separately using fixed-effect meta-analysis with inverse variance weights (METAL software). Additionally, heritability was estimated in 2 cohorts. RESULTS: Heritability estimates for fish and EPA+DHA consumption ranged from 0.13-0.24 and 0.12-0.22, respectively. A significant GWA for fish intake was observed for rs9502823 on chromosome 6: each copy of the minor allele (FreqA = 0.015) was associated with 0.029 servings/day (~1 serving/month) lower fish consumption (P = 1.96x10-8). No significant association was observed for EPA+DHA, although rs7206790 in the obesity-associated FTO gene was among top hits (P = 8.18x10-7). Post-hoc calculations demonstrated 95% statistical power to detect a genetic variant associated with effect size of 0.05% for fish and 0.08% for EPA+DHA. CONCLUSIONS: These novel findings suggest that non-genetic personal and environmental factors are principal determinants of the remarkable variation in fish consumption, representing modifiable targets for increasing intakes among all individuals. Genes underlying the signal at rs72838923 and mechanisms for the association warrant further investigation.
Source: PLoS ONE
Authors: Dariush Mozaffarian, Hassan S Dashti, Mary K Wojczynski, Audrey Y Chu, Jennifer A Nettleton, Satu Männistö, Kati Kristiansson, Mägi Reedik, Jari Lahti, Denise K Houston, Marilyn C Cornelis, Frank J. A van Rooij, Maria Dimitriou, Stavroula Kanoni, Vera Mikkilä, Lyn M Steffen, Marcia C de Oliveira Otto, Lu Qi, Bruce Psaty, Luc Djousse, Jerome I Rotter, Kennet Harald, Markus Perola, Harri Rissanen, Antti Jula, Fischer Krista, Evelin Mihailov, Mary F Feitosa, Julius S Ngwa, Luting Xue, Paul F Jacques, Mia-Maria Perälä, Aarno Palotie, Yongmei Liu, Nike A Nalls, Luigi Ferrucci, Dena Hernandez, Ani Manichaikul, Michael Y Tsai, Jessica C Kiefte-de Jong, Albert Hofman, André G Uitterlinden, Loukianos Rallidis, Paul M Ridker, Lynda M Rose, Julie E Buring, Terho Lehtimäki, Mika Kähönen, Jorma Viikari, Rozenn Lemaitre, Veikko Salomaa, Paul Knekt, Andres Metspalu, Ingrid B Borecki, L. Adrienne Cupples, Johan G Eriksson, Stephen B Kritchevsky, Stefania Bandinelli, David Siscovick, Oscar H Franco, Panos Deloukas, George Dedoussis, Daniel I Chasman, Olli Raitakari, Toshiko Tanaka
Institutions: Tufts University, Jean Mayer Human Nutrition Research Center on Aging, Washington University in St. Louis, Brigham and Women's Hospital, The University of Texas Health Science Center at Houston, Finnish Institute for Health and Welfare, University of Tartu, University of Helsinki, Folkhälsans Forskningscentrum, Wake Forest University Health Sciences, Wake Forest University, Harvard University, Erasmus MC, Netherlands Consortium for Healthy Ageing, Harokopio University of Athens, Queen Mary University of London, William Harvey Research Institute, University of Turku, University of Minnesota, University of Washington, University of California, Los Angeles, The Lundquist Institute, Harbor–UCLA Medical Center, Institute for Molecular Medicine Finland, Boston University, Howard University, United States Department of Agriculture, Helsinki University Hospital, National Institutes of Health, National Institute on Aging, University of Virginia, Leiden University, University General Hospital Attikon, Tampere University, Fimlab (Finland), University of Tampere, Tampere University Hospital, Turku University Hospital, Framingham Heart Study, Azienda Sanitaria di Firenze, New York Academy of Medicine, King Abdulaziz University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,382
Funders: U.S. Department of Agriculture, Donald W. Reynolds Foundation, Amgen, Massachusetts General Hospital, Wake Forest University, School of Medicine, Boston University, Foundation for Cardiovascular Research, Helsingin Yliopisto, Johns Hopkins University, Wellcome Trust, Cedars-Sinai Medical Center, Broad Institute, European Commission, European Science Foundation, Fondation Leducq, ZonMw, Kela, Academy of Finland, Erasmus Medisch Centrum, Suomen Kulttuurirahasto, Ministero della Salute, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Juho Vainion Säätiö, Novo Nordisk, Signe ja Ane Gyllenbergin Säätiö, Emil Aaltosen Säätiö, Sydäntutkimussäätiö, Tampereen Tuberkuloosisäätiö, Orionin Tutkimussäätiö, Tartu Ülikool, Paavo Nurmen Säätiö, Turun Yliopistollinen Keskussairaala, Centre for Medical Systems Biology, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute on Drug Abuse, National Human Genome Research Institute, National Eye Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Dental and Craniofacial Research, National Center for Research Resources, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities
Awards: G100949702, G1022294208, G1023702118, G1028935811, G1037428335, GWAS of Venous Thrombosis, G1083180012, G1083489883, G1083756078, G1093446944, G1118486281, Biomarker Research Alliance for Diagnosing Heart Disease in the Ageing European Population, G1214533002, G1220223050, G1238898755, G1248102086, G125972088, G1261793039, Genetic Determinants of Visceral Adiposity, CORONARY HEART DISEASE AND STROKE, G1271251741, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G1338396984, G136105103, G1364610698, G1407109571, G1409423729, G1416987869, DYNAMICS OF HEALTH,AGING, AND BODY COMPOSITION, G1462415530, G1490530680, G1495020029, G150102659, G1528515809, G1560231001, G1560275704, G1576437321, G1584998369, CORONARY HEART DISEASE AND STROKE, G1717613936, G1718233269, G1789381357, G1798569254, G1856075850, G1891033315, G1921953589, G1955273565, G1982334678, G2070131968, G2078309758, G2098337849, G2111339113, G214012886, G2146332128, G215333750, G2175624253, DYNAMICS OF HEALTH, AGING, AND BODY COMPOSITION, G2194386449, G2214254730, BBMRI - Large Prospective Cohorts, G2230772921, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G229684361, G2313542652, Biomarker for Cardiovascular Risk Assessment in Europe, G2391884931, G247538147, G2495888254, G250621538, G2513778610, G2513955590, G2539352280, G2548880556, G2562080342, G2585438117, G25881238, G2608303928, CORONARY HEART DISEASE &STROKE IN THE ELDERLY, G270907595, Study of Addiction: Genetics and Environment, G278975345, G2800149121, G2815873878, International Consortium to Identify Genes and Interactions Controlling Oral Clef, Genes and Environment Initiatives in Type 2 Diabetes, G2851966638, G2857511458, G2918387404, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING, G2962705247, G297113894, G300339986, G3042145041, G3045517347, GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTS, HEALTH ABC--COORDINATING UNIT, Genome-wide association studies of prematurity and its complications, G3219722387, G3220743633, G3294437106, G3294852582, Cancer Epidemiology Cohort in Male Health Professionals, G3362311673, G3426488059, G34347772, G343705321, G353731103, G3540777072, G3560030053, G3572394825, G3586617177, G3588481721, G3647016462, G3648845612, G3667269547, G36937976, G3696925611, GWA for Gene-Environment Interaction Effects Influencing CHD, G374919288, G3799582765, G3821133518, G3839646794, G3860090032, G395156118, G3978296121, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, FHS-SCAN Genome Wide Association Scan for Atherosclerosis Pathway Genes, G4008331704, G4102267556, G4122201895, G4139205196, G4145745212, GENCAC - Birmingham Field Center, G423252844, G4321089066, G4353734806, G4376790518, G4429312988, G445457422, G4503763930, G4507648799, G4560968858, G4562300860, Genome Wide Association Coordinating Center, G4580637148, G4587988226, G4652745033, G4671189754, G4765588100, G4814686505, G4824283243, G4878925441, G4919155732, G4932516547, G5026578359, G5084050915, GWAS of longitudinal blood pressure profiles from young adulthood to middle-age, G5121713029, G5184311545, G5206110354, G5251985303, Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts, G528395701, G5339631484, G536099884, G5369020747, G537455924, Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood, G5424457750, G5439707361, G5457026379, G5474452856, G5479317095, G5483271793, G5522185877, The Pathobiology of Nephrolithiasis, G5540580309, Epidemiology of Venous Thrombosis and Pulmonary Embolism, G558986044, G55962079, G5632764457, G5652732059, G5654179670, G5654214539, NUTRITION RESEARCH FOR HEALTH AGING AND PREVENTION OF CHRONIC DISEASE, G5709863906, G5770909501, G581554933, G581887176, G5909482378, Genetic Risk to Stroke in Smokers and Nonsmokers in Two Ethnic Groups, G5969426970, CHS Events Follow-up Study, G6008908520, G6038209881, G6147499578, G6164432047, G6177097893, G6204895930, G6205002944, G6226795708, G6333306906, G6343431347, G6355767702, G6401035755, G6493395989, G6525491790, G6576172577, G6613352697, G6682689995, FAMILY STUDY OF COCAINE DEPENDENCE, G670738241, CHS-Transition Phase, G6802942620, TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN, G6894932656, G6902273418, G693077865, G6967858299, GENCAC-Data Coordinating Center, G7093047072, G7129568825, G7176672723, G731636440, G7333524540, MESA, G7364523043, Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3, G7477626106, G7522350138, G7560939899, G7693351332, G7697152668, G77250574, Eye and Vision Genomics Training Program, G786153652, ReliabilitY of opto-Transceivers for Health Monitoring Systems, Women's Health Study: Continued Follow-up, Cancer Epidemiology Cohort in Male Health Professionals, G793702358, G7958292912, G7962241407, G7970570881, G80149192, G814381192, G816910144, G8260701975, G8267674335, G8276458029, G8376726714, G8443806426, GENCAC - CENTRAL BIOCHEMISTRY LABORATORY, G8505307412, G8506930532, GENOMIC SCAN FOR ATHEROSCLEROSIS PATHWAY GENES IN AFRICAN-AMERICANS FROM FHS-SCAN, G858805679, G861947890, G8631571027, G870807107, G8716920314, HISPANIC SECONDARY STROKE PREVENTION INITIATIVE, G878552033, G890705022, G8927421343, G8930697277, G9000015747, G9000025954, G9000028264, G9000043482, G9000058182, G9000065698, G9000069684, G9000080822, G9000099730, G9000122174, G9000126117, G9000134904, G9000152345, G9000157792, G9000216949, G9000286278, G9000294209, G9000313681, Diabetes Research Center (DRC), From GWAS loci to blood pressure genes, variants & mechanisms - Renewal, UCLA Clinical and Translational Science Institute, G901343485, G905887895, G931818222, G945304896, G991334795, G992154238
OpenAlex ID: W2772375799