Year: 2017
Type: preprint
Abstract: With the recent breakthroughs in immunotherapy as curative treatments in certain tumor types, there has been renewed interest in the relationship between immunity and tumor growth.Although we are gaining a greater understanding of the complex interplay of immune modulating components in the tumor microenvironment, the specific role that tumor cells play in shaping the immune milieu is still not well characterized.In this review, we focus on how mutant Kras tumor cells contribute to tumor immunity, with a specific focus on processes induced directly or indirectly by the oncogene. KRAS' IMMUNOLOGISTICSThe discovery that oncogenic Kras could induce nuclear factor (NF)-κB activation in fibroblasts and epithelial cells provided the first direct evidence of its capacity to drive proinflammatory signaling in transformed cells (Finco et al. 1997;
Authors: Jane Cullis, Shipra Das, Dafna Bar-Sagi
Institution: New York University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2772685043