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Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress

Year: 2017
Type: article
Abstract: Significance Invertebrates are productive models for understanding basic molecular principles that link cytokine-mediated inflammatory pathways to aging in humans. Here, we use a high-throughput dsRNA screen to determine that the multifunctional Drosophila cytokine, GBP, is a ligand for the hitherto orphan GPCR, Mthl10. Through genetic manipulation of the GBP/Mthl10 axis in larvae and adult flies, we are able to demonstrate how organismal longevity is interconnected to immunological, metabolic, and stress-protective responses. Our results provide a molecular basis for hypothesizing that a successful defense against environmental insults—be they pathogenic inflammation or noninfective challenges—will ultimately reduce lifespan.
DOI: 10.1073/pnas.1712453115
Authors: Eui Jae Sung, Masasuke Ryuda, Hitoshi Matsumoto, Outa Uryu, Masanori Ochiai, Molly E. Cook, Na Young Yi, Huanchen Wang, James W. Putney, Gary S. Bird, Stephen B. Shears, Yoichi Hayakawa
Institutions: National Institutes of Health, National Institute of Environmental Health Sciences, Saga University, Hokkaido University, Institute of Low Temperature Science, Hokkaido University, North Carolina Central University
Language: English
Subfield: Aging
Open Access status: green
OpenAlex ID: W2772844141
FWCI: 2.213
Cites: 37
Cited by: 49
Related to: 10