Work

From ATP synthase dimers to C-ring conformational changes: unified model of the mitochondrial permeability transition pore

Year: 2017

Type: article

Abstract: Mitochondrial permeability transition (mPT) is a phenomenon of sudden increase of the permeability of the mitochondrial inner membrane in response to excessive accumulation of calcium and/or oxidative stress. It is generally agreed that mPT is caused by the opening of a large channel (mitochondrial permeability transition pore or mPTP) that allows flux of ions and small molecules up to 1.5 kDa across the inner membrane. Activation of mPT causes mitochondrial membrane depolarization and a loss of mitochondrial function. It is believed that mPT is a central event leading to the mitochondrial dysfunction and is the major cause of cell damage in a wide range of pathologies from acute conditions related to stroke and heart attack to neurodegenerative diseases 1 , 2 . Currently the molecular composition of mPTP is not entirely understood and the nature of the core “pore” part of mPTP remains subject of hot debates. This significantly limits both our basic understanding of one of the most fundamental steps leading to cell death and the translational use of the mPTP as a drug target for disease treatment.

Source: Cell Death and Disease

DOI: 10.1038/s41419-017-0042-3

Authors: Giuseppe Federico Amodeo, Maria E. Solesio, Evgeny V. Pavlov

Institution: New York University

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,990