Work

Rubicon: LC 3‐associated phagocytosis and beyond

Year: 2017

Type: review

Abstract: Rubicon (Rubcn) was initially identified as a component of the Class III PI3K complex and a negative regulator of canonical autophagy and endosomal trafficking. However, Rubicon has attracted the most notoriety because of its critical role in LC3-associated phagocytosis (LAP), a form of noncanonical autophagy that utilizes some components of the autophagy machinery to process extracellular cargo. Additionally, Rubicon has been identified as a key modulator of the inflammatory response and viral replication. In this review, we discuss the known functions of Rubicon in LAP and other signaling pathways and examine the disease pathologies associated with Rubicon dysfunction in animal models and humans.

Source: FEBS Journal

DOI: 10.1111/febs.14354

Authors: Sing‐Wai Wong, Payel Sil, Jennifer Martinez

Institutions: University of North Carolina at Chapel Hill, National Institutes of Health, National Institute of Environmental Health Sciences

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,000