Work

On the helical arrangements of protein molecules

Year: 2017

Type: article

Abstract: Helical structures are prevalent in biology. In the PDB, there are many examples where protein molecules are helically arranged, not only according to strict crystallographic screw axes but also according to approximate noncrystallographic screws. The preponderance of such screws is rather striking as helical arrangements in crystals must preserve an integer number of subunits per turn, while intuition and simple packing arguments would seem to favor fractional helices. The article provides insights into such questions, based on stereochemistry, trigonometry, and topology, and illustrates the findings with concrete PDB structures. Updated statistics of Sohncke space groups in the PDB are also presented.

Source: Protein Science

DOI: 10.1002/pro.3356

Authors: Zbigniew Dauter, Mariusz Jaskolski

Institutions: Argonne National Laboratory, National Cancer Institute, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Adam Mickiewicz University in Poznań, Polish Academy of Sciences

Language: English

Topic: Enzyme Structure and Function

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W2773434458

FWCI:

Cites: 33

Cited by: 8

Related to: 10