Work

Naa1 Nicotinamide Riboside Supplementation Reduces Aortic Stiffness and Blood Pressure in Middle-aged and Older Adults

Year: 2017

Type: article

Abstract: in systolic/diastolic BPs and pulse pressure averaged 11.8/e1.6,12.7/e1.8and 10.3/e1.2mmHg and 13.4,14.4 and 11.5 mmHg, respectively (P < 0.0001).Cornel voltage and index averaged 1.18 mV and 114.8 mV Â ms.The Cornell voltages were 0.104/0.086and 0.082/0.105mV higher in relation to brachial 24-h and asleep systolic/diastolic BP (per 1-SD), respectively, and 0.088/0.90mV and 0.087/0.107mV higher in relation to central BP.The corresponding estimates for the Cornel indexes were 9.6/8.6 and 8.2/105 mV Â ms peripherally and 8.6/8.9 and 8.8/10.7 mV Â ms centrally.The regression slopes were similar for brachial and central BP (P !0.054).Associations of the ECG measurements with awake BP, PP, the augmentation ratio and pressure amplification did not reach significance.Conclusions: The diurnal rhythm of peripheral and central BP run in parallel.Central BP does not improve the association of Cornell voltage or index with peripheral BP.

Source: Artery Research

DOI: 10.1016/j.artres.2017.10.021