Insulin resistance and colon cancer promotion in rats on diets differing in fat, energy, and starch
Year: 1998
Type: dissertation
Abstract: McKeown-Eyssen and Giovannucci proposed that hyperinsulinemia associated with insulin resistance (IR) promotes colorectal cancer (CRC).In this thesis, £irst, it was hypothesized that, if IR led to CRC.IR should appear pnor to evidence of CRC promotion.It was shown that a high saturateci fat diet given to F344 rats increased IR pnor to evidence of CRC promotion.Second, it was hypothesized that, if IR led to CRC, the degree of promotion/iibition of CRC by different diets should be correlated with the degree of promotiodibition of IR.Effects of dietary energy, fat, n-3 fatty acids and starch were tested on IR and CRC promotion.The degree of CRC promotion was correlated with the degree of I R (r=0.65, p<0.00 1).In addition, energy intake and body weight were highly correlated with IR and CRC promotion.It was concluded that increased cimilating energy (giucose, triglycerides) may lead to both IR and CRC.was always there when 1 needed help.Without his insighîfid perspectives, patience and guidance, this work would not have been accomplished.I am very gratefbl to have had the opportunity to work with him.
Author: Niloofar Koohestani
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2773856627