Work

Biology of Bone Sarcomas and New Therapeutic Developments

Year: 2017

Type: review

Abstract: Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma, Ewing sarcoma and chondrosarcoma each subdivided in diverse histological entities. They are clinically characterised by a relatively high morbidity and mortality, especially in children and adolescents. Although these tumours are histologically, molecularly and genetically heterogeneous, they share a common involvement of the local microenvironment in their pathogenesis. This review gives a brief overview of their specificities and summarises the main therapeutic advances in the field of bone sarcoma.

Source: Calcified Tissue International

DOI: 10.1007/s00223-017-0372-2

Authors: Hannah K. Brown, Kristina Schiavone, François Gouin, Marie-Françoise Heymann, Dominique Heymann

Institutions: Inserm, University of Sheffield, Université de Nantes, Nantes Université, Institut de Cancérologie de l'Ouest

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,990