Work

Nonhuman Primate Models of Zika Virus Infection, Immunity, and Therapeutic Development

Year: 2017

Type: review

Abstract: Zika virus is a re-emerging flavivirus transmitted primarily by arthropod vectors. The recent devastating outbreak of Zika virus in Brazil was preceded by the slow global encroachment of this virus over many decades. To date, significant research efforts are underway to understand the spread and the unique pathogenesis of this virus; with the intent to rapidly develop vaccines and therapeutics. Several model systems have emerged to study Zika. This review will focus on the use of nonhuman primates to model Zika infection.

Source: The Journal of Infectious Diseases

DOI: 10.1093/infdis/jix540

Authors: Christa E Osuna, James B Whitney

Institutions: Beth Israel Deaconess Medical Center, Harvard University, Ragon Institute of MGH, MIT and Harvard

Language: English

Topic: Mosquito-borne diseases and control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases