Year: 2016
Type: dissertation
Study design: Observational Study
Abstract: The relationship between folate (a B vitamin important in DNA synthesis and methylation reactions) and cancer risk among BRCA1/2 mutation carriers with a genetic predisposition for developing breast cancer is unclear. Therefore this study investigated the association between plasma folate and folic acid supplement use, along with other B vitamins, and breast cancer risk in BRCA1/2 mutation carriers. Women with high plasma folate concentrations had significantly increased risks for breast cancer, compared with women with low plasma folate concentrations. However, women who never used folic acid-containing supplements had significantly increased risks for breast cancer. Similarly, never use of vitamin B6- or vitamin B12-containing supplements tended to be associated with increased breast cancer risk. These findings support a â Uâ -shaped association of folate and breast cancer risk and suggests that moderate B vitamin supplement use may be protective for BRCA1/2-associated breast cancer, however BRCA1/2 mutation carriers should be cautious of over-supplementation.
Source: TSpace (University of Toronto)
Author: Shana Jean Kim
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
Funders: Cancer Research UK, University of Oxford
OpenAlex ID: W2774416449