Work

Transition‐Metal‐Catalyzed Selective Functionalization of C(sp3)−H Bonds in Natural Products

Year: 2017

Type: review

Abstract: Direct functionalization of natural products is important for studying the structure–activity and structure–property relationships of these molecules. Recent advances in the transition‐metal‐catalyzed functionalization of C(sp3)−H bonds, the most abundant yet inert bonds in natural products, have allowed natural product derivatives to be created selectively. Strategies to achieve such transformation are reviewed.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201710330

Authors: Rashad R. Karimov, John F. Hartwig

Institution: University of California, Berkeley

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: Mechanism and Development of Catalysts for the Synthesis of Amines, Ethers, and S, Catalytic Functionalization of C-H Bonds with Main Group Reagents, G6487154649, Mechanism and Rational Development of Catalytic Carbon-Carbon Bond-Forming Reacti