Atomically Precise Au 25 (SG) 18 Nanoclusters: Rapid Single-Step Synthesis and Application in Photothermal Therapy
Year: 2017
Type: article
Abstract: Remarkable recent advances on Au 25 (SR) 18 nanoclusters have led to significant applications in catalysis, sensing, and magnetism. However, the existing synthetic routes are complicated, particularly for the water-soluble Au 25 (SG) 18 nanoclusters. Here, we report a single-step concentration and temperature-controlled method for rapid synthesis of the Au 25 (SG) 18 nanoclusters in as little as 2 h without the need for low-temperature reaction or even stirring. A systematic time-based investigation was carried out to study the effects of volume, concentration, and temperature on the synthesis of these nanoclusters. Further, we discovered for the first time that the Au 25 (SG) 18 nanoclusters exhibit excellent photothermal activities in achieving 100% cell death for MDA-MB-231 breast cancer cells at a power of 10 W/cm 2 using an 808 nm laser source, demonstrating applications toward photothermal therapy.
Institution: The University of Texas at El Paso
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Funders: Division of Intramural Research, National Institute of Allergy and Infectious Diseases, University of Texas System, Philadelphia Foundation, National Institutes of Health, University of Texas at El Paso, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, Division of Materials Research, National Institute on Minority Health and Health Disparities
OpenAlex ID: W2774495152