Work

Interplay of autophagy, receptor tyrosine kinase signalling and endocytic trafficking

Year: 2017

Type: review

Abstract: Vesicular trafficking events play key roles in the compartmentalization and proper sorting of cellular components. These events have crucial roles in sensing external signals, regulating protein activities and stimulating cell growth or death decisions. Although mutations in vesicle trafficking players are not direct drivers of cellular transformation, their activities are important in facilitating oncogenic pathways. One such pathway is the sensing of external stimuli and signalling through receptor tyrosine kinases (RTKs). The regulation of RTK activity by the endocytic pathway has been extensively studied. Compelling recent studies have begun to highlight the association between autophagy and RTK signalling. The influence of this interplay on cellular status and its relevance in disease settings will be discussed here.

Source: Essays in Biochemistry

DOI: 10.1042/ebc20170091

Authors: Jane Fraser, Ainara G. Cabodevilla, Joanne Simpson, Noor Gammoh

Institutions: Edinburgh Cancer Research, University of Edinburgh

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,565