Work

A complex molecular switch directs stress-induced cyclin C nuclear release through SCFGrr1-mediated degradation of Med13

Year: 2017

Type: article

Abstract: In response to oxidative stress, cells must choose either to live or to die. Here we show that the E3 ligase SCFGrr1 mediates the destruction of Med13, which releases cyclin C into the cytoplasm and results in cell death. The Med13 SCF degron is most likely primed by the Cdk8 kinase and marked for destruction by the MAPK Slt2.

Source: Molecular Biology of the Cell

DOI: 10.1091/mbc.e17-08-0493

Authors: David C. Stieg, Stephen D. Willis, Vidyaramanan Ganesan, Kai Li Ong, Joseph Scuorzo, Mia Song, Julianne Grose, Randy Strich, Katrina F. Cooper

Institutions: Rowan University, Brigham Young University

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Center for Research Resources

Awards: Stress regulated mitochondrial dynamics, Comprehensive Biology: Exploiting the Yeast Genome, Comprehensive Biology: Exploiting the Yeast Genome, Stress induced signaling and cyclin C regulation in yeast, Investigating the partitioning of glucose to lipids versus respiration, an undergraduate-based approach to dissect a pivotal point of metabolic control, G9000251020, G9000298539

OpenAlex ID: W2774787840

FWCI: 1.788

Cites: 90

Cited by: 38

Related to: 10