Work

Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography

Year: 2017

Type: article

Abstract: C-CSar), a radiolabelled synthetic N-methylglycine (sarcosine) conjugate of cholic acid, is a novel molecular imaging technique that enables quantitative assessment of the individual transport steps involved in hepatic secretion of conjugated bile acids. Here, we present the method and discuss its potential clinical and scientific applications based on findings in the first human study of healthy subjects and patients with cholestasis. We also present a clinical example of a patient studied during and six months after an episode of drug-induced cholestatic liver injury.

Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI: 10.1016/j.bbadis.2017.11.016

Authors: Nikolaj Ørntoft, Kim Frisch, Peter Ott, Susanne Keiding, Michael Sørensen

Institution: Aarhus University Hospital

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Aase og Ejnar Danielsens Fond, Aage og Johanne Louis-Hansens Fond