Work

P165 Higher Blood Pressure in Youth Is Attributable to a Combination of Higher Cardiac Output and Higher Total Peripheral Resistance

Year: 2017

Type: article

Abstract: Background: It has been proposed that high blood pressure (BP) in young people is due to high cardiac output (CO) with normal total peripheral resistance (TPR) – a hyperkinetic/hyperdynamic circulation. We investigated this in a large, population- based cohort of adolescents. Methods: The study was conducted on 2091 participants in the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective population-based birth cohort study, aged 17. BP measurement and echocardiography was performed and heart rate (HR), stroke volume (SV) and TPR calculated. Data are means (SD). Results: Table 1 shows selected characteristics of the sample. Higher quintiles of systolic BP were associated with higher SV, higher HR and higher TPR. However, the proportional contribution made by SV, HR and TPR to mean arterial pressure differed little by systolic BP quintile (stroke volume (32–34%) heart rate (25–29%) and TPR (39–41%)). Variable Males (n = 939) Females (n = 1152) All (n = 2091) y (0.3) (0.3) (0.3) kg/m2 (3.7) (4.2) (4.0) mmHg 11)/64(8) 9)/65(7) 11)/65(8) bpm 0 0 0 L/min 1.0) 0.8) 0.9) ml 3 1 3 mmHg ml/min (5.9) (6.0) (6.0) Conclusions: Higher blood pressure is attributable to a combination of higher cardiac output (i.e. SV×HR) and higher TPR in a population-based sample of adolescents. There is no evidence of a disproportionate contribution from CO at higher BP levels.

Source: Artery Research

DOI: 10.1016/j.artres.2017.10.114