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Precision Medicine in Pediatric Neurooncology: A Review

Year: 2017
Type: review
Abstract: Central nervous system tumors are the leading cause of cancer related death in children. Despite much progress in the field of pediatric neurooncology, modern combination treatment regimens often result in significant late effects, such as neurocognitive deficits, endocrine dysfunction, secondary malignancies, and a host of other chronic health problems. Precision medicine strategies applied to pediatric neurooncology target specific characteristics of individual patients' tumors to achieve maximal killing of neoplastic cells while minimizing unwanted adverse effects. Here, we review emerging trends and the current literature that have guided the development of new molecularly based classification schemas, promising diagnostic techniques, targeted therapies, and delivery platforms for the treatment of pediatric central nervous system tumors.
DOI: 10.1021/acschemneuro.7b00388
Authors: Aaron Y. Mochizuki, Isaura M. Frost, Melina B. Mastrodimos, Ashley S. Plant, Anthony C. Wang, Theodore B. Moore, Robert M. Prins, Paul S. Weiss, Steven J. Jonas
Institutions: University of California, Los Angeles, Children's Hospital of Orange County, University of California System, UCLA Jonsson Comprehensive Cancer Center, California NanoSystems Institute, Broad Center
Language: English
Subfield: Genetics
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W2775389840
FWCI: 0.232
Cites: 169
Cited by: 24
Related to: 10