Work

Modeling metabolism of the human gut microbiome

Year: 2017

Type: review

Abstract: The human gut microbiome plays an important part in human health. The complexity of the microbiome makes it difficult to determine the detailed metabolic functions and cross-talk occurs between the individual species. In silico systems biology studies of the microbiome can help to identify metabolite exchanges among gut microbes. Constraint-based reconstruction and analysis methods use biochemically accurate genome-scale metabolic networks of microorganisms to simulate metabolism between species in a given microbiome and help generate novel hypotheses on microbial interactions. Here, we review metabolic modeling studies that have investigated metabolic functions of the gut microbiome.

Source: Current Opinion in Biotechnology

DOI: 10.1016/j.copbio.2017.12.005

Authors: Stefanía Magnúsdóttir, Ines Thiele

Institutions: University of Luxembourg, Luxembourg Centre for Systems Biomedicine

Language: English

Topic: Microbial Metabolic Engineering and Bioproduction

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,530

Funders: Fonds National de la Recherche Luxembourg, Fonds De La Recherche Scientifique - FNRS