Year: 2017
Type: dissertation
Study design: Observational Study
Abstract: Whether mammographic density, a strong predictor of breast cancer risk, is associated with breast cancer risk factors in women at an increased risk of familial breast cancer is unclear. Therefore, this study evaluated the associations between reproductive, hormonal, anthropometric, and lifestyle risk factors and measures of mammographic density (percent density, dense area, non-dense area) among high-risk, BRCA mutation-negative women. Overall, parity and body weight were inversely associated with percent density and positively associated with non-dense area. Increasing height was positively associated with percent density and inversely associated with non-dense area. A later age at smoking and alcohol initiation were positively associated with mammographic density. Among postmenopausal women only, past smoking was inversely associated with mammographic density. In premenopausal women only, an increasing duration of smoking was inversely associated with mammographic density. These findings suggest that mammographic density is associated with several modifiable breast cancer risk factors among this high-risk cohort.
Source: TSpace (University of Toronto)
Author: Olivia Moran
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2776057715