Year: 2017
Type: article
Abstract: Recent breakthroughs in the field of cryo-electron microcopy (cryo-EM) provide new prospects for determination of the structures of a variety of medically important macromolecular assemblies. The prospect that the determination of protein structures at atomic resolution will no longer be limited by size, or by the need for crystallization represents a significant and exciting horizon in structural biology. I will discuss the use of cryo-EM methods for the analysis of structures of medically relevant multi-protein complexes and viruses, and highlight how these advances can be applied to the development of improved therapeutic agents.
Author: Sriram Subramaniam
Institution: National Institutes of Health
Language: English
Subfield: Structural Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2776345034