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Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

Year: 2017
Type: article
Source: Cancer Cell
DOI: 10.1016/j.ccell.2017.11.012
Authors: Hiroyoshi Kunimoto, Cem Meydan, Abbas Nazir, Justin Whitfield, Kaitlyn Shank, Franck Rapaport, Rebecca Maher, Elodie Pronier, Sara C. Meyer, Francine E. Garrett-Bakelman, Martin Tallman, Ari Melnick, Ross L. Levine, Alan H. Shih
Institutions: Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, University of Connecticut, UConn Health, University of Basel, University Hospital of Basel, Weill Cornell Medical Center, University of Virginia
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: bronze
Funders: Nora van Meeuwen Häfliger Stiftung, Robert Wood Johnson Foundation, Dana Foundation, American Society of Hematology, Chemotherapy Foundation, Novartis, Leukemia and Lymphoma Society, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Lady Tata Memorial Trust, Astellas Foundation for Research on Metabolic Disorders, Swiss Bridge Foundation, National Institutes of Health, Swiss Re Foundation, National Cancer Institute
Awards: G1421565595, G1433521944, G2140937474, Genetic and epigenetic basis of relapse in acute myeloid leukemia, Analysis of TET2 function in acute leukemia, G3839152751, G4052644630, G410872540, G4253949428, G4508373442, G4871940255, G502731794, G5746680569, G5958620772, G6995731259, G7141003014, Genetic and functional insights into the pathogenesis of myeloproliferative neoplasms, Mechanisms and targeting of oncogenic MAPK signaling in myeloid malignancies, G9000079197, Cancer Center Support Grant, Synergistic role of signaling and epigenetics in leukemic transformation
OpenAlex ID: W2776489049
FWCI: 5.734
Cites: 48
Cited by: 98
Related to: 10