Work

Preparation and evaluation of PCL-PEG-PCL micelles as potential nanocarriers for ocular delivery of dexamethasone.

Year: 2018

Type: article

Abstract: OBJECTIVES: Micelles have been studied as nanoparticulate drug delivery systems for improving the topical ocular delivery of hydrophobic drugs. The objective of this study was to develop and characterize dexamethasone-loaded polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) micelles to improve patient compliance and enhance the ocular bioavailability of poorly water-soluble drugs. MATERIALS AND METHODS: corneal permeability were also determined. RESULTS: at 34°C. The TEM results exhibited the successful formation of spherical micelles. The size of the prepared micelles was approximately 40 nm. Formulated micelles sustained the release of the incorporated dexamethasone for 5 days. CONCLUSION: permeability tests indicated that PCL-PEG-PCL micelles can be suitable candidates for the ocular delivery of dexamethasone and, likely, other hydrophobic drugs.

Source: PubMed Central

DOI: 10.22038/ijbms.2017.26590.6513

Authors: Mitra Alami-Milani, Parvin Zakeri-Milani, Hadi Valizadeh, Roya Salehi, Mitra Jelvehgari

Institution: Tabriz University of Medical Sciences

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Tabriz University of Medical Sciences