Bone disease in monoclonal gammopathy of undetermined significance: results from a screened population-based study
Year: 2017
Type: article
Study design: Observational Study
Abstract: < .001). Overall, the risk of fractures was not significantly increased in individuals with MGUS (hazard ratio [HR], 1.19; 95% confidence interval [CI], 0.94-1.50). Men with MGUS had a significantly increased fracture risk, compared with other men (HR, 1.46; 95% CI, 1.03-2.08). Our results show that although individuals with MGUS do not have decreased BMD, bone volume is increased, and MGUS men have a 50% increased fracture risk. These results indicate that bone disease and fractures in MGUS differ from processes known from osteoporosis.
Source: Blood Advances
Institutions: University of Iceland, National University Hospital of Iceland, Karolinska University Hospital, Karolinska Institutet, Icelandic Heart Association, National Cancer Institute, National Cancer Institute, Center for Cancer Research, National Institutes of Health, National Institute on Aging, Memorial Sloan Kettering Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,800
OpenAlex ID: W2776907385