The ups and downs of DNA repair biomarkers for PARP inhibitor therapies.
Year: 2011
Type: article
Abstract: PARP inhibitors are emerging as a valuable new drug class in the treatment of cancer. Recent discoveries make a compelling case for the complexity of DNA repair biomarker evaluation and underscore the need to examine at multiple biomarkers in a relational manner. This review updates the current trends in DNA repair biomarker strategies in use for the PARP inhibitors and describes the impact of many DNA repair biomarkers on PARP inhibitor benefit in the cancer clinic.
Source: Europe PMC (PubMed Central)
Authors: Xiaozhe Wang, David T Weaver
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W277781478