Antisaccadic Eye Movements as a Correlate for Response Inhibition and White Matter Integrity in Mild Traumatic Brain Injury
Year: 2015
Type: dissertation
Study design: Observational Study
Abstract: Antisaccades are thought to involve higher level inputs from neural centers involved in rapid eye movement inhibition and control. Previous work has demonstrated that performance on the antisaccade task can help in assessment of injury in acute and/or chronic Mild Traumatic Brain Injury (mTBI). We validated antisaccade performance in mTBI assessment against gold standard assessments of symptom burden, diffusion tensor imaging, and a neuropsychological test of response inhibition. Significant deficits in antisaccade median latency and prosaccade mean duration were found between patient groups and controls, despite overall integrity of the pupillary light reflex; the former was correlated with loss of white matter integrity in the splenium of the corpus callosum in acute mTBI. Furthermore, antisaccade median latency was also associated with poor performance on executive functioning tasks, and greater symptom burden in the acute patients. This research suggests that the antisaccade task is useful as a neurological marker for mTBI.
Source: TSpace (University of Toronto)
Author: Windsor Kwan‐Chun Ting
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2777956844