Work

Chromatin and nucleosome dynamics in DNA damage and repair

Year: 2017

Type: preprint

Abstract: Chromatin is organized into higher-order structures that form subcompartments in interphase nuclei. Different categories of specialized enzymes act on chromatin and regulate its compaction and biophysical characteristics in response to physiological conditions. We present an overview of the function of chromatin structure and its dynamic changes in response to genotoxic stress, focusing on both subnuclear organization and the physical mobility of DNA. We review the requirements and mechanisms that cause chromatin relocation, enhanced mobility, and chromatin unfolding as a consequence of genotoxic lesions. An intriguing link has been established recently between enhanced chromatin dynamics and histone loss.

Source: Genes & Development

DOI: 10.1101/gad.307702.117

Authors: Michael H. Hauer, Susan M. Gasser

Institutions: University of Basel, Friedrich Miescher Institute

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: National Science Foundation, Novartis Foundation, Boehringer Ingelheim Fonds, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

OpenAlex ID: W2778217919

Cites: 180

Cited by: 345

Related to: 10