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ANP32A dysregulation contributes to abnormal megakaryopoiesis in acute megakaryoblastic leukemia

Year: 2017

Type: article

Abstract: Acute megakaryoblastic leukemia (AMKL) is a rare type of leukemia characterized by indefinite proliferation of megakaryocytes 1 . The prognosis of AMKL is dismay and no target therapy is available that urges for development of novel therapy 2 . Recent research proposed that forcing AMKL cells to undergo polyploidization and differentiation was a good therapeutic strategy for AMKL 3 . Thus, regulators controlling megakaryopoiesis could be potential targets for AMKL therapy. ANP32A gene was implied to be a potential regulator of hematopoiesis and megakaryopoiesis 4 . However, its role in blood remains unclear.

Source: Blood Cancer Journal

DOI: 10.1038/s41408-017-0031-x