Work

Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria

Year: 2017

Type: article

Study design: Observational Study

Abstract: Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contribute to causing the higher biomass found in severe disease. Compared with patients without a history of previous malaria, patients with previous malaria carried a lower parasite biomass with similar fever duration at presentation, suggesting that host immunity reduces the PMR.

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofx169

Authors: Hugh W Kingston, Aniruddha Ghose, Katherine Plewes, Haruhiko Ishioka, Stije J Leopold, Richard J Maude, Sanjib Paul, Benjamas Intharabut, Kamorat Silamut, Charles Woodrow, Nicholas P J Day, Kesinee Chotivanich, Nicholas M Anstey, Amir Hossain, Nicholas J White, Arjen M Dondorp

Institutions: Mahidol University, Churchill Hospital, Charles Darwin University, University of Oxford, Menzies School of Health Research, Mahidol Oxford Tropical Medicine Research Unit, Chittagong Medical College

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,053

Funders: Wellcome Trust, National Health and Medical Research Council

OpenAlex ID: W2778565363

FWCI: 1.541

Cites: 15

Cited by: 15

Related to: 10