Year: 2015
Type: dissertation
Abstract: Genomic analysis of breast cancer (BC) has revealed the existence of recurrent copy number losses and mutations in GATA3 and RUNX1. Interestingly, these are predominantly found in luminal tumors. GATA3 and RUNX1 are transcription factors that help specify mammary luminal lineages. To test whether BC-associated genetic aberrations of GATA3 and RUNX1 contribute to luminal-like tumorigenesis, I generated cohorts of female mice in which Gata3 and Runx1 were deleted in mammary epithelium. In addition, I have successfully generated transgenic mice that express a breast tumor-derived Gata3 mutant. To date, twelve-months old females with copy number loss of Gata3 and Runx1 are mostly tumor-free (approximately 3% and 13% of Gata3 and Runx1 conditional heterozygous have developed mammary tumours, respectively).
Source: TSpace (University of Toronto)
Author: Nayasta Ademmana Kusdaya
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2779171906