Work

(Radio)fluoroclick Reaction Enabled by a Hydrogen‐Bonding Cluster

Year: 2017

Type: article

Abstract: We have developed a widely applicable nucleophilic (radio)fluoroclick reaction of ynamides with readily available and easy‐to‐handle KF(18F). The reactions exhibited high functional‐group tolerance and needed only an ambient atmosphere. This 18F addition to C−C unsaturated bonds proceeded with extraordinarily high radiochemical yields.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201711341

Authors: Xiaojun Zeng, Junling Li, Chin K. Ng, Gerald B. Hammond, Bo Xu

Institutions: Donghua University, University of Louisville

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: green