Year: 2017
Type: review
Abstract: Alzheimer's disease (AD) is behaviorally identified by progressive memory impairment and pathologically characterized by the triad of β-amyloid plaques, neurofibrillary tangles, and neurodegeneration. Genetic mutations and risk factors have been identified that are either causal or modify the disease progression. These genetic and pathological features serve as basis for the creation and validation of mouse models of AD. Efforts made in the past quarter-century have produced over 100 genetically engineered mouse lines that recapitulate some aspects of AD clinicopathology. These models have been valuable resources for understanding genetic interactions that contribute to disease and cellular reactions that are engaged in response. Here we focus on mouse models that have been widely used stalwarts of the field or that are recently developed bellwethers of the future. Rather than providing a summary of each model, we endeavor to compare and contrast the genetic approaches employed and to discuss their respective advantages and limitations. We offer a critical account of the variables which may contribute to inconsistent findings and the factors that should be considered when choosing a model and interpreting the results. We hope to present an insightful review of current AD mouse models and to provide a practical guide for selecting models best matched to the experimental question at hand.
Source: Molecular Neurodegeneration
Authors: Joanna L. Jankowsky, Hui Zheng
Institution: Baylor College of Medicine
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,090
Awards: Modeling genetic modifiers of cognitive reserve in AD, G4564146506, Interrogating the link between aging and AD with temporally-controlled transgenes, Decoding the role of diverse astrocyte populations in aging and AD, Plasticity of the entorhinal-hippocampal circuit as a vulnerability in AD, Knockin mouse models of Alzheimer's Disease, G6364469473, Pathophysiology of APP in vivo, ROLE OF TFEB IN TAUOPATHY, Deconstructing the pathogenic effect of APP in memory circuits, G9000302932, Knockin mouse models of Alzheimer's Disease, ROLE OF TFEB IN TAUOPATHY
OpenAlex ID: W2779463443