Phenols as Diamagnetic T2‐Exchange Magnetic Resonance Imaging Contrast Agents
Year: 2017
Type: article
Abstract: Although T2‐exchange (T2ex) NMR phenomena have been known for decades, there has been a resurgence of interest to develop T2ex MRI contrast agents. One indispensable advantage of T2ex MR agents is the possibility of using non‐toxic and/or bio‐compatible diamagnetic compounds with intermediate exchangeable protons. Herein a library of phenol‐based compounds is screened and their T2ex contrast (exchange relaxivity, r2ex) at 9.4 T determined. The T2ex contrast of phenol protons allows direct detection by MRI at a millimolar concentration level. The effect of chemical modification of the phenol on the T2ex MRI contrast through modulation of exchange rate and chemical shift was also studied and provides a guideline for use of endogenous and exogenous phenols for T2ex MRI contrast. As a proof‐of‐principle application, phenol T2ex contrast can be used to detect enzyme activity in a tyrosinase‐catalyzed catechol oxidation reaction.
Source: Chemistry - A European Journal
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
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OpenAlex ID: W2779465883