Work

Production of packed nanospray emitters with integrated emitter-end frits for liquid-chromatography mass spectrometry

Year: 2018

Type: article

Abstract: This protocol describes how to frit the emitter-end of a pulled silica capillary and subsequently pack it to produce a robust integrated column.Integrating liquid chromatography separations directly into the emitter of a nanospray source for mass spectrometry offers improved sensitivity and resolution.This is achieved by reducing post-separation dead volume.The method described here provides an optimized setup to maximize sensitivity and separation.

Source: Protocol Exchange

DOI: 10.1038/protex.2017.154

Authors: Nathan Hendricks, Nathan Hendricks, Leo Wang

Institutions: City Of Hope National Medical Center, City of Hope

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

OpenAlex ID: W2781556539

FWCI:

Cites: 2

Cited by: 1

Related to: 10