Dietary curcumin intervention targets both white adipose tissue inflammation and brown adipose tissue thermogenesis
Year: 2017
Type: dissertation
Abstract: Increased adipose tissue inflammation and reduced energy expenditure are among the key causative factors of obesity and its related metabolic disorders. Therapeutic tools targeting these two pathological events are desired. Previous studies have mainly attributed the body-weight lowering effect of curcumin and other dietary polyphenols to their anti-inflammatory properties in adipose tissues and elsewhere. We found that in high-fat diet (HFD)-fed mice, dietary curcumin intervention reduced not only epididymal adipose tissue macrophage infiltration but also the ratio of M1-like versus M2-like macrophages. In vitro curcumin treatment also reduced pro-inflammatory cytokine expression in macrophages and adipocytes. Furthermore, curcumin intervention in HFD-fed mice increased energy expenditure and body temperature in response to cold challenge, associated with increased brown adipocyte uncoupling protein 1 expression. We conclude that curcumin-intervention plays a dual modulatory role in preventing metabolic disorders by attenuating white adipose tissue inflammation and increasing brown adipocyte activity.
Source: TSpace (University of Toronto)
Author: Zhuolun Song
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2781658297