Year: 2017
Type: preprint
Abstract: Lower frequency, feedback, activity in the alpha and beta range is thought to predominantly originate from infragranular cortical layers, whereas feedforward signals in the gamma range stem largely from supragranular layers. Distinct anatomical and spectral channels may therefore play specialized roles in communication within hierarchical cortical networks; however, empirical evidence for this organization in humans is limited. We leverage high precision MEG to test this proposal, directly and non-invasively, in human participants during visually guided actions. Visual alpha activity mapped onto deep cortical laminae, whereas visual gamma activity predominantly arose from superficial laminae. This laminar-specificity was echoed in sensorimotor beta and gamma activity. Visual gamma activity scaled with task demands in a way compatible with feedforward signaling. For sensorimotor activity, we observed a more complex relationship with feedback and feedforward processes. Distinct frequency channels thus operate in a laminar-specific manner, but with dissociable functional roles across sensory and motor cortices.
DOI: 10.1101/226274
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: G1294512332, Core support for the Wellcome Trust Centre for Neuroimaging, G1884315490, G1920791764, Non-invasive laminar electrophysiology in humans, G33445216, Building multi-site clinical research capacity in Magnetoencephalography (MEG), G4314457631, G523534345, An investigation into the neurocomputational role of brain oscillations in human motor control for health and disease., Core support for the Wellcome Trust Centre for Neuroimaging., G7123984414, An investigation into the neurocomputational role of brain oscillations in human motor control for health and disease.
OpenAlex ID: W2781984262