Work

Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer

Year: 2018

Type: article

Abstract: cytotoxic T lymphocytes infiltrating the tumor and improved long-term tumor-free survival in the mouse cohort. Tumor-free mice were resistant to rechallenge by the same but not unrelated (4T1 breast cancer) cells. Treatment with the combination of TNFR2-blocking antibody and a CD25-targeted antibody also resulted in enhanced inhibition of tumor growth in a syngeneic 4T1 mouse model of breast cancer. Thus, the combination of a TNFR2 inhibitor and an immunotherapeutic stimulant may represent a more effective treatment strategy for various cancers.

Source: Science Signaling

DOI: 10.1126/scisignal.aan0790

Authors: Yingjie Nie, Jiang He, Hidekazu Shirota, Anna L. Trivett, De Yang, Dennis M. Klinman, Joost J. Oppenheim, Xin Chen

Institutions: National Cancer Institute, Center for Cancer Research, Guizhou Provincial People's Hospital, University of Macau

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Natural Science Foundation of China, Guizhou Science and Technology Department, Universidade de Macau, National Institutes of Health, National Cancer Institute

Awards: Role of T Regulatory Cell Suppression in Autoimmunity and Cancer, Mechanism of action and therapeutic utility of immunostimulatory CpG oligonucleo, G3854263839, G4420560370, G6482184549, G6744086265, G6749223077, G7045653347, R848对系统性红斑狼疮的免疫治疗作用与机制研究, G8599529644, G8964768773

OpenAlex ID: W2782059509

FWCI: 3.189

Cites: 65

Cited by: 74

Related to: 10