Work

Metal-free regioselective hydrochlorination of unactivated alkenes via a combined acid catalytic system

Year: 2018

Type: article

Abstract: A combined acid HCl/DMPU-acetic acid catalytic system was used in the hydrochlorination of a wide range of unactivated alkenes. This hydrochlorination strategy is remarkably greener than previous reported methods in terms of high atom efficiency, no toxic waste generated and metal-free process. The higher efficiency, compared with other commercially available HCl reagents, was augmented by the good regioselectivity and functionality tolerance found. A stepwise mechanism for this hydrochlorination process was proposed based on kinetic studies.

Source: Green Chemistry

DOI: 10.1039/c7gc03665e

Authors: Shengzong Liang, Gerald B. Hammond, Bo Xu

Institutions: University of Louisville, Donghua University

Language: English

Topic: Chemical Synthesis and Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: green

Funders: National Natural Science Foundation of China, National Institute of General Medical Sciences