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Urine Tuberculosis Lipoarabinomannan Predicts Mortality in Hospitalized Human Immunodeficiency Virus-Infected Children

Year: 2018

Type: article

Study design: Observational Study

Abstract: Despite diagnostic performance limitations, urine lipoarabinomannan (LAM) predicts death in human immunodeficiency virus (HIV)–infected adults with tuberculosis. Pediatric data are limited. Among 137 hospitalized HIV-infected children, mortality was 4.9-fold higher among those with positive LAM (127 vs 31 per 100 person-years; adjusted hazard ratio, 4.92; 95% confidence interval [CI], 1.79–13.49; P = .002). Lipoarabinomannan identifies HIV-infected children at risk for death potentially missed by respiratory sampling. NCT02063880.

Source: Clinical Infectious Diseases

DOI: 10.1093/cid/ciy011

Authors: Sylvia M LaCourse, Lisa M Cranmer, Irene N Njuguna, John Gatimu, Joshua Stern, Elizabeth Maleche-Obimbo, Judd L Walson, Dalton Wamalwa, Grace C John-Stewart, Patricia B Pavlinac

Institutions: University of Washington, Emory University, Children's Healthcare of Atlanta, Kenyatta National Hospital, University of Nairobi, The Childhood Acute Illness and Nutrition Network

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Firland Foundation, National Institutes of Health, Center for AIDS Research, University of Washington, National Institute of Allergy and Infectious Diseases, Fogarty International Center, National Institute of Child Health and Human Development, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1211141729, G1389856746, G1898711858, G2213881162, Impact of maternal HIV on Mycobacterium tuberculosis infection among peripartum women and their infants, G3435361946, G378552126, G627155725, G691201058, G9000009745, G9000070302, G9000088351, G9000132270, G9000158781, STD and AIDS Research Training Grant

OpenAlex ID: W2782128398

FWCI: 1.21

Cites: 10

Cited by: 13

Related to: 10